[A canine model of complete ischemic brain regulated with perfusion method (author's transl)]

A model of complete ischemic brain regulated with a perfusion method in dogs was produced by interrupting the main arteries at the base of the brain and perfusing the arterial blood from the femoral artery of the dog to the lt. hemisphere through a tube cannulated into the rt. M.C.A. retrogradely. The cerebral blood flow in the lt. hemisphere is regulated by the infused blood volume which can be regulated with a pump. Hyperemic brain, normal brain, incomplete ischemic brain and complete ischemic brain can be produced in the entire lt. hemisphere at will in all dogs. Recirculation is also possible by means of the regulation of blood flow after various degrees of ischemia. This model also allows for the study of the various effects of drugs on the ischemic brain and research on the sequential pathological and chemical changes without individual differences among the dogs. This model should be valuable for investigation of not only ischemia but also cerebral metabolism, cerebral pharmacology and cerebral blood circulation.