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Oxyfederine and propranolol--a controlled trial in angina pectoris
British Journal of Clinical Pharmacology
|November 1, 1980
Summary
Oxyfedrine and propranolol effectively treat chronic stable angina pectoris, showing comparable symptom relief and exercise tolerance improvements. Both drugs were well-tolerated with minimal side effects in this randomized trial.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Chronic stable angina pectoris is a prevalent condition requiring effective treatment.
- Current therapeutic options aim to improve symptoms and exercise capacity.
Purpose of the Study:
- To compare the efficacy and safety of oxyfedrine, propranolol, and placebo in patients with chronic stable angina pectoris.
Main Methods:
- A double-blind, crossover, randomized trial involving 30 patients.
- Assessed symptom levels, ECG responses to graded exercise, and biochemical markers.
- Compared oxyfedrine (32 mg TID), propranolol (120 mg TID), and placebo.
Main Results:
- Both oxyfedrine and propranolol significantly improved symptom levels (P < 0.05).
- Significant improvements in ST index were observed with propranolol (P < 0.02) and oxyfedrine (P < 0.05).
- No significant hematological or biochemical changes were noted; side effects were infrequent and minor.
Conclusions:
- Oxyfedrine demonstrates comparable efficacy to propranolol in managing chronic stable angina.
- Oxyfedrine is a safe and well-tolerated therapeutic option for angina pectoris.