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Sweet's syndrome in infancy

S Itami, K Nishioka

    The British Journal of Dermatology
    |October 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Infantile Sweet's syndrome is a rare skin condition presenting as tender, red plaques in infants. Early diagnosis and corticosteroid treatment are crucial for effective management.

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    Area of Science:

    • Pediatric Dermatology
    • Dermatopathology
    • Neonatal Medicine

    Background:

    • Sweet's syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory condition.
    • While typically seen in adults, infantile Sweet's syndrome presents unique diagnostic challenges.
    • Understanding early clinical and histological features is vital for prompt diagnosis in neonates.

    Observation:

    • A 3-month-old Japanese infant presented with fever and tender, erythematous, elevated plaques on the face and buttocks.
    • Histopathological examination revealed a dermal perivascular neutrophil infiltrate with nuclear debris and swollen endothelial cells.
    • Lesions showed resistance to antibiotics but a significant response to oral corticosteroids.

    Findings:

    • The clinical presentation and histopathological findings were consistent with infantile Sweet's syndrome.

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  • The characteristic neutrophil infiltrate in the dermis is a key diagnostic marker.
  • The dramatic response to corticosteroids further supported the diagnosis.

    • Implications:

    • This case highlights the importance of considering Sweet's syndrome in the differential diagnosis of febrile neutrophilic dermatoses in infants.
    • Prompt recognition and initiation of corticosteroid therapy can lead to rapid symptom resolution.
    • Further research into the specific triggers and long-term outcomes of infantile Sweet's syndrome is warranted.