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Hydroxyproline centiles for normal adolescent boys and girls
Clinical Orthopaedics and Related Research
|November 1, 1978
Summary
Centiles for 24-hour urinary total hydroxyproline aid in tracking growth and treatment effects in children with orthopedic conditions like scoliosis. These centiles, derived from a longitudinal study, correlate adolescent height velocity with hydroxyproline levels.
Area of Science:
- Biochemistry
- Pediatrics
- Orthopedics
Background:
- Assessing growth in pediatric orthopedic conditions, such as scoliosis, presents challenges with traditional anthropometric methods.
- 24-hour urinary total hydroxyproline serves as a potential biomarker for monitoring skeletal growth and treatment efficacy.
Purpose of the Study:
- To establish centiles for 24-hour urinary total hydroxyproline in normal adolescent schoolchildren.
- To evaluate the utility of these centiles in monitoring growth and treatment effects in orthopedic diseases.
Main Methods:
- A 5-year longitudinal study was conducted on 100 normal adolescent schoolchildren.
- Hydroxyproline levels and growth assessments (height velocity) were measured three times annually.
Main Results:
- Centiles for 24-hour urinary total hydroxyproline were calculated from the study data.
- A correlation was observed between the rate of growth (height velocity) and hydroxyproline levels in adolescents.
Conclusions:
- 24-hour urinary total hydroxyproline centiles are valuable tools for monitoring growth in pediatric orthopedic patients.
- Hydroxyproline levels provide a quantifiable measure that complements anthropometric assessments, particularly in conditions affecting growth measurement.