Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new method for evaluating antiarrhythmic drug efficacy

M Sami, H Kraemer, D C Harrison

    Circulation
    |December 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Quasiparticle Poisoning of Superconducting Qubits from Resonant Absorption of Pair-Breaking Photons.

    Physical review letters·2024
    Same author

    The ratios of iron to oxygen, iron to colour and oxygen to colour in the blood of men and women.

    The Journal of physiology·2010
    Same author

    Fiber optics oximeter-densitometer for cardiovascular studies.

    Applied optics·2010
    Same author

    Specific cardiac indications for routine lidocaine use.

    Anesthesia progress·2009
    Same author

    The distribution of the orphan bombesin receptor subtype-3 in the rat CNS.

    Neuroscience·2003
    Same author

    Increased cortical expression of the orexin-1 receptor following permanent middle cerebral artery occlusion in the rat.

    Neuroscience letters·2002

    This study establishes standards for evaluating antiarrhythmic drugs by differentiating drug effects from natural variations in premature ventricular complexes (PVCs). It defines sensitivity thresholds for treadmill and ambulatory monitoring to ensure reliable drug efficacy assessment.

    Area of Science:

    • Cardiology
    • Clinical Pharmacology
    • Medical Device Technology

    Background:

    • Premature ventricular complexes (PVCs) are common arrhythmias.
    • Distinguishing drug-induced changes from spontaneous PVC variability is crucial for antiarrhythmic drug trials.
    • Existing methods lack standardized criteria for assessing drug efficacy.

    Purpose of the Study:

    • To develop and validate standards for assessing antiarrhythmic drug efficacy.
    • To establish criteria for differentiating drug effects from placebo response in PVCs.
    • To define sensitivity thresholds for treadmill exercise testing and ambulatory electrocardiographic monitoring.

    Main Methods:

    • Twenty-one male patients with chronic ischemic heart disease and PVCs participated.
    • Symptom-limited treadmill tests and 24-hour ambulatory monitoring were performed before and after placebo.

    Related Experiment Videos

  • Linear regression analysis determined confidence intervals for PVC frequency variability.

    • Main Results:

    • Sensitivity thresholds were 1.2 PVCs/min for treadmill tests and 2.2 PVCs/hour for ambulatory monitoring.
    • All patients met the ambulatory monitoring threshold, but only 38% met the treadmill threshold at baseline.
    • A 65-68% reduction in PVCs was needed to demonstrate 95% confidence in antiarrhythmic efficacy.

    Conclusions:

    • Established standards can reliably distinguish antiarrhythmic drug effects from spontaneous PVC variability.
    • The developed model provides a framework for assessing antiarrhythmic drug efficacy across diverse patient populations.
    • Treadmill testing and ambulatory monitoring require specific PVC frequency thresholds for valid drug effect assessment.