Plasma angiotensin II and the control of diabetes mellitus

Plasma angiotensin II was measured in twenty patients with poorly controlled non-ketotic diabetes mellitus, and again when blood glucose control improved. Plasma angiotensin II fell significantly improved control, both when patients were supine and fasting overnight, and when studied after 4 h ambulation. The change occurred with improved short-term and longer-term control. It is concluded that the degree of blood glucose control is important when assessing the renin-angiotensin system in diabetic patients.