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Related Experiment Videos

Abuse potential of loperamide

J H Jaffe, M Kanzler, J Green

    Clinical Pharmacology and Therapeutics
    |December 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This study investigated the abuse potential of loperamide (Imodium). Researchers found that loperamide, in its current form, poses little risk for abuse, unlike codeine.

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    Area of Science:

    • Pharmacology
    • Addiction Research

    Background:

    • Loperamide is an over-the-counter medication for diarrhea.
    • Concerns exist regarding the potential for loperamide abuse due to its opioid-like properties.

    Purpose of the Study:

    • To evaluate the abuse potential of the currently marketed form of loperamide.
    • To compare the subjective and objective effects of loperamide with codeine and placebo.

    Main Methods:

    • Two double-blind studies were conducted.
    • Study I involved dose-ranging of loperamide in individuals with a history of illicit drug use.
    • Study II compared loperamide (60 mg) with codeine (96 mg) and placebo in former opioid addicts.

    Main Results:

    • Codeine induced pupillary constriction, while loperamide and placebo did not.

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  • Loperamide produced detectable subjective effects in over half of subjects but was poorly "liked" and less frequently identified as "dope" compared to codeine.
  • Loperamide did not produce the same subjective effects or physiological responses as codeine.

    • Conclusions:

    • In its current formulation (capsules with magnesium stearate), loperamide presents a low risk for abuse.
    • The abuse potential of loperamide appears significantly lower than that of codeine.