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Dermatitis associated with Evans blue dye

G P Lupton, R B Odom

    Contact Dermatitis
    |October 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Allergic contact dermatitis after lymphangiography can be caused by Evans blue dye, not just the contrast medium. Skin testing with both agents is crucial for accurate diagnosis and management.

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    Area of Science:

    • Dermatology
    • Radiology
    • Allergology

    Background:

    • Lymphangiography is a diagnostic imaging procedure.
    • Allergic reactions to lymphangiography agents can occur.
    • Dermatitis following lymphangiography requires careful etiological investigation.

    Observation:

    • A 73-year-old woman presented with allergic contact dermatitis and urticaria post-lymphangiography.
    • Skin testing revealed hypersensitivity to Evans blue dye, a lymphatic marker.
    • Ethiodol, the contrast medium, did not elicit a positive skin test reaction.

    Findings:

    • Extravasation of Ethiodol was noted on X-ray in one leg, but dermatitis affected both.
    • Positive intracutaneous skin test to Evans blue dye suggests it as the causative agent.

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  • The pattern of dermatitis distribution and skin test results highlight diagnostic complexities.

    • Implications:

    • Intracutaneous skin testing is recommended over epicutaneous testing for suspected lymphangiography-related dermatitis.
    • Testing for hypersensitivity to both the dye marker and contrast medium is essential.
    • Understanding sensitization routes may inform future diagnostic protocols and patient safety.