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Hydralazine-induced liver injury
Digestive Diseases and Sciences
|November 1, 1980
Summary
Hydralazine can cause liver injury, even after long-term use. This case shows drug-induced liver damage with centrilobular necrosis, resolving after hydralazine withdrawal.
Area of Science:
- Hepatology
- Clinical Pharmacology
- Toxicology
Background:
- Hydralazine is a vasodilator used to treat hypertension.
- Drug-induced liver injury (DILI) is a significant clinical concern.
- Long-term hydralazine use can be associated with various adverse effects.
Observation:
- A 68-year-old male patient developed liver injury after three years of hydralazine therapy.
- The hepatic injury presented without any hypersensitivity reaction.
- Liver biopsy revealed centrilobular zonal necrosis.
Findings:
- Discontinuation of hydralazine led to clinical, biochemical, and histological recovery.
- Challenge tests and serial liver biopsies confirmed hydralazine as the causative agent.
- The liver injury pattern was characteristic of drug-induced hepatotoxicity.
Implications:
- This case highlights the potential for hydralazine to cause delayed-onset liver injury.
- It underscores the importance of considering drug etiology in unexplained hepatic dysfunction.
- Monitoring liver function may be warranted in patients on long-term hydralazine treatment.