Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paracetamol pharmacokinetics in thyroid disease

J C Forfar, A Pottage, A D Toft

    European Journal of Clinical Pharmacology
    |October 1, 1980
    PubMed
    Summary

    Thyroid disease alters paracetamol (acetaminophen) pharmacokinetics. Thyrotoxicosis speeds absorption and elimination, reducing peak levels, while hypothyroidism slows both, with minimal changes from euthyroid states.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Constraints to counting bioluminescence producing cells by a commonly used transgene promoter and its implications for experimental design.

    Scientific reports·2019
    Same author

    Thyroid hormone replacement - a counterblast to guidelines.

    The journal of the Royal College of Physicians of Edinburgh·2018
    Same author

    The Microwell-mesh: A high-throughput 3D prostate cancer spheroid and drug-testing platform.

    Scientific reports·2018
    Same author

    A humanised tissue-engineered bone model allows species-specific breast cancer-related bone metastasis in vivo.

    Journal of tissue engineering and regenerative medicine·2017
    Same author

    Determining Protease Substrates Within a Complex Protein Background Using the PROtein TOpography and Migration Analysis Platform (PROTOMAP).

    Methods in molecular biology (Clifton, N.J.)·2017
    Same author

    Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis.

    British journal of cancer·2015

    Area of Science:

    • Pharmacology
    • Endocrinology
    • Drug Metabolism

    Background:

    • Thyroid hormones significantly influence metabolic processes.
    • Altered thyroid status (thyrotoxicosis and hypothyroidism) may impact drug pharmacokinetics.
    • Understanding paracetamol (acetaminophen) disposition in thyroid dysfunction is crucial for patient care.

    Purpose of the Study:

    • To investigate the effects of thyrotoxicosis and hypothyroidism on the absorption, distribution, and elimination of oral paracetamol.
    • To compare paracetamol pharmacokinetics in patients with untreated thyroid disease versus euthyroid states.

    Main Methods:

    • Pharmacokinetic study involving oral paracetamol administration.
    • Analysis of paracetamol absorption, distribution, and elimination parameters.

    Related Experiment Videos

  • Comparison of drug disposition in patients with thyrotoxicosis (n=7) and hypothyroidism (n=4) before and after treatment, against euthyroid controls.

    • Main Results:

    • Faster paracetamol absorption and shorter plasma half-life observed in untreated thyrotoxicosis compared to euthyroid state.
    • Increased total body clearance of paracetamol in thyrotoxic patients, leading to lower peak concentrations.
    • Reduced absorption and elimination rates in hypothyroid patients, though not significantly different from euthyroid.
    • A larger apparent volume of the central compartment in thyrotoxic patients.

    Conclusions:

    • Thyrotoxicosis significantly alters paracetamol pharmacokinetics, affecting absorption rate, clearance, and half-life.
    • Hypothyroidism shows a trend towards reduced absorption and elimination, but with less pronounced effects than thyrotoxicosis.
    • Observed changes in paracetamol disposition in thyroid disease may explain variations in therapeutic response and potential toxicity.