Related Experiment Video
Updated: Jul 4, 2026

10:01
Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures
Published on: March 12, 2018
Influence of hirudin on endotoxin-induced disseminated intravascular coagulation (DIC) in weaned pigs
Abstract:
In weaned pigs endotoxin infusion caused pathological changes in the clotting system typical of consumption coagulopathy and DIC resulting in circulatory disturbances. Infusion of the specific thrombin inhibitor hirudin prevented the endotoxin-induced disorders such as haematological changes, microthrombosis in various organs and the increase in right ventricular pressure and in respiratory rate.

