[Effect of lithium oxybutyrate on the bioelectrical activity of the cortex and subcortical structures of the rabbit...

Intravenous administration of 10 mg/kg of lithium hydroxybutyrate to rabbits exerts a depressant effect on spontaneous bioelectrical activity of the cortex and subcortical structures of the brain, with this effect distributing from the cortex to the subcortex. The drug reduces the electrical excitation of the motor cortex, caudate nucleus, thalamus, posterior hypothalamus and reticular formation of the midbrain. The convulsive threshold of the amygdaloid complex decreases. No substantial changes were detected in hypocampal electrical excitability. By its depressant effect lithium hydroxybutyrate compares very favourably with lithium chloride.