[Isoniazid distribution and biogenic amine metabolism in brain structures]

The effect of isoniazid (200 mg/kg) on metabolism of biogenic amines in different parts of the brain was studied in acute experiments on white rats. Isoniazid was detected in all test organs one hour after the administration, with metabolism of biogenic amines changed. The level of biogenic amines is related not only to the drug distribution pattern but also to the specificity of its participation in the biochemical processes, restricting the synthesis of monoamines.