[Influence of antidepressants on the hypotensive effect of clofeline in rats]

It has been shown in experiments on unanesthesized rats with normal arterial blood pressure that the antidepressants azaphen, pyrazidol and inkasan as well as imipramine and amitryptyline reduce the hypotensive effect of clofelin. With the dosage build-up the antidepressants themselves start to exert the hypotensive effect. However, the antagonism to clofelin in relation to the arterial blood pressure is maintained. It is suggested that such an effect is consequent on the impairment of noradrenaline neuronal uptake induced by the antidepressants.