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Related Experiment Videos

Semen analysis in subfertile balanced-translocation carriers

D Marmor, J L Taillemite, J Van den Akker

    Fertility and Sterility
    |November 1, 1980
    PubMed
    Summary

    Subfertile men with balanced translocations showed varied sperm quality, similar to those with normal karyotypes. Chromosome analysis is recommended for infertile men, as semen analysis alone cannot predict translocation presence.

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    Medecine et maladies infectieuses·2017

    Area of Science:

    • Human Genetics
    • Reproductive Medicine
    • Cytogenetics

    Background:

    • Balanced translocations are chromosomal rearrangements that can affect fertility.
    • Subfertility affects a significant portion of the male population.
    • Previous studies suggest sex chromosome aberrations severely impact sperm parameters, unlike autosomal rearrangements.

    Purpose of the Study:

    • To compare semen analysis results between subfertile men with balanced translocations and those with normal karyotypes.
    • To evaluate the necessity of chromosome analysis in routine infertility investigations.

    Main Methods:

    • Analysis of spermograms from 19 subfertile men carrying balanced translocations.
    • Comparison of sperm count, motility, and morphology with data from subfertile men with normal karyotypes.

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    Main Results:

    • Sperm parameters in translocation carriers were widely distributed, with some achieving normal values.
    • No statistically significant differences were observed in sperm count, motility, or morphology compared to controls.
    • Autosomal rearrangements did not consistently lead to severe oligospermia or azoospermia.

    Conclusions:

    • Semen analysis alone is insufficient for predicting autosomal karyotype rearrangements.
    • Chromosome analysis should be integrated into the routine evaluation of subfertile males.
    • The mechanisms linking translocation heterozygosity to reduced male fertility require further investigation, potentially involving meiotic studies.