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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
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Inflammatory Bowel Disease II: Crohn's Disease

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Crohn's disease
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Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
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Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Colonic dysfunction in diabetes mellitus

W M Battle, W J Snape, A Alavi

    Gastroenterology
    |December 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Diabetic patients with severe constipation show absent postprandial gastrocolonic responses, suggesting autonomic neuropathy. Mild constipation cases exhibit delayed responses, while medications improve motility in all diabetic patients.

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    Area of Science:

    • Gastroenterology
    • Diabetology
    • Neurology

    Background:

    • Diabetes mellitus is frequently associated with gastrointestinal dysmotility.
    • Constipation is a common symptom in diabetic patients, potentially linked to autonomic neuropathy.

    Purpose of the Study:

    • To investigate colonic myoelectrical and motor activity in diabetic patients with varying degrees of constipation.
    • To explore the relationship between colonic motility, gastric emptying, and peripheral nerve function in diabetes.

    Main Methods:

    • Measurement of colonic myoelectrical and motor activity in 12 diabetic patients and normal subjects.
    • Assessment of gastric emptying and peripheral nerve conduction.
    • Administration of neostigmine and metoclopramide to evaluate drug effects on colonic motility.

    Main Results:

    • Normal subjects exhibited a rapid postprandial increase in colonic activity.
    • Diabetic patients with severe constipation showed no postprandial colonic response, while those with mild constipation had a delayed response.
    • No significant correlation was found between colonic motility and gastric emptying or peripheral nerve conduction.
    • Neostigmine and metoclopramide enhanced colonic activity in all diabetic subjects.

    Conclusions:

    • Severe constipation in diabetes mellitus may be attributed to an absent postprandial gastrocolonic response, indicative of autonomic neuropathy.
    • Pharmacological agents can improve colonic motility in diabetic patients, irrespective of constipation severity.