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Related Experiment Videos

Factors affecting spasticity

P W Nathan

    International Rehabilitation Medicine
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Spinal cord lesions cause spasticity, preventing normal walking. Reducing neural input to motor neurons can permanently decrease spasticity and restore movement.

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    Area of Science:

    • Neuroscience
    • Motor Control
    • Spinal Cord Injury

    Background:

    • The spinal cord contains the neural circuitry for locomotion (stepping, walking, running).
    • Spinal cord lesions disrupt motor control, leading to spasticity, characterized by exaggerated responses to stimuli.
    • Spasticity involves muscle over-activity and spread of excitation, hindering voluntary movement.

    Purpose of the Study:

    • To explain the mechanism of spasticity following spinal cord lesions.
    • To identify factors that normally prevent spasticity in intact nervous systems.
    • To propose a method for restoring normal movement by reducing spasticity.

    Main Methods:

    • Analysis of the physiological basis of spasticity in spinal cord injury.
    • Identification of inhibitory mechanisms (corticospinal tract, Renshaw inhibition) that regulate spinal cord excitability.

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  • Conceptual framework for reducing motor neuron excitability.

    • Main Results:

    • Spasticity arises from excessive neuronal excitability and after-discharges in the spinal cord after lesions.
    • Normal motor control relies on descending inhibition and local spinal inhibitory circuits.
    • Reducing the overall input to motor neurons alleviates spasticity.

    Conclusions:

    • Spasticity is a state of heightened general excitability of spinal motor neurons.
    • Permanent reduction of spasticity is achievable by decreasing the input to motor neurons.
    • Restoring normal movement patterns is possible once spasticity is controlled.