[Acute mixed portal hypertension. Experimental study (author's transl)]

Experimental studies were conducted in dogs to establish a new model for portal hypertension. The model chosen depends on partial obstruction of the portal vein to obtain a portal pressure of 11 +/- 4 ml. and the injection of 600 U. of secretin over a period of 35 min. The validity of the model was demonstrated by hemodynamic studies which resulted in a portal pressure, mesenteric blood flow, and mesenteric vascular resistances similar to those observed in clinical practice (hepatic cirrhosis).