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Related Experiment Videos

Chronic measles encephalitis in mice

K W Rammohan, D E McFarlin, H F McFarland

    The Journal of Infectious Diseases
    |October 1, 1980
    PubMed
    Summary

    Hamster neurotropic measles virus causes acute encephalopathy in BALB/c mice. SJL/J mice survivors develop chronic measles encephalitis, characterized by brain inflammation and viral antigen.

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    Area of Science:

    • Virology
    • Neuroscience
    • Immunology

    Background:

    • Measles virus can cause central nervous system disease.
    • Animal models are crucial for understanding viral encephalitis pathogenesis.

    Purpose of the Study:

    • To investigate the neuropathogenesis of measles virus in different mouse strains.
    • To describe a novel model of chronic measles encephalitis.

    Main Methods:

    • Intracerebral inoculation of hamster neurotropic measles virus into weanling BALB/c and SJL/J mice.
    • Clinical observation for signs of neurological disease.
    • Pathological examination of brains for inflammation and viral antigen.
    • Detection of measles virus-specific antibodies.

    Main Results:

    • BALB/c mice predominantly developed acute, fatal encephalopathy.
    • SJL/J mice showed resistance to acute disease, with approximately one-third developing chronic encephalitis weeks post-inoculation.
    • Chronic encephalitis in SJL/J mice featured significant brain inflammation, measles viral antigen (primarily in the limbic system, cerebellum, and brain stem), and detectable antibodies.
    • This study is the first to describe chronic measles encephalitis in an inbred host model.

    Conclusions:

    • SJL/J mice provide a valuable inbred model for studying the mechanisms of chronic measles encephalitis.
    • The findings highlight the diverse neuropathic potential of measles virus depending on host genetics.

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