Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Astrocytic differentiation in medulloblastoma

R O Barnard, H Pambakian

    Journal of Neurology, Neurosurgery, and Psychiatry
    |November 1, 1980
    PubMed
    Summary

    This study describes a rare cerebellar medulloblastoma that transforms into malignant astrocytoma. It highlights the potential for primitive neuroepithelial tumors to differentiate into glial tumors.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fatal cytophagic panniculitis and haemophagocytic syndrome.

    Clinical and experimental dermatology·1998
    Same author

    Fibroelastoma: case report and review of the literature.

    Heart (British Cardiac Society)·1998
    Same author

    Caecocystoplasty and bilateral oophorectomy followed by chemotherapy for diffuse, non-Hodgkins lymphoma of the ovary involving the bladder. Case report.

    European journal of gynaecological oncology·1997
    Same author

    High grade non-Hodgkins stage IEB primary malignant lymphoma of the cervix and upper vagina. A case report.

    European journal of gynaecological oncology·1996
    Same author

    Escherichia coli endophthalmitis: a rare presentation of renal parenchymal malakoplakia.

    British journal of urology·1995
    Same author

    Sebaceous adenoma of parotid gland--a rare tumour diagnosed by fine needle aspiration cytology.

    Cytopathology : official journal of the British Society for Clinical Cytology·1994

    Area of Science:

    • Neuro-oncology
    • Pathology
    • Cancer Biology

    Background:

    • Medulloblastoma is a primitive neuroepithelial tumor typically found in the cerebellum.
    • Astrocytomas are glial tumors that can vary in malignancy.
    • Understanding tumor differentiation is crucial for diagnosis and treatment.

    Observation:

    • A unique case of cerebellar medulloblastoma exhibiting transitional features towards malignant fibrillary astrocytoma was observed.
    • Extensive subpial infiltration by undifferentiated cells was noted in the cerebellum.
    • The astrocytic component was confirmed via glial fibrillary acidic protein (GFAP) staining.

    Findings:

    • The tumor showed a transformation in the brainstem, presenting as a diffuse astrocytoma.
    • This case demonstrates the capacity of primitive neuroepithelial neoplasms to undergo differentiation.
    • Glial fibrillary acidic protein (GFAP) positivity confirmed the astrocytic nature of the differentiated component.

    Implications:

    • This finding expands the understanding of medulloblastoma's potential for cellular differentiation.
    • It suggests a possible spectrum of glial tumor development from primitive neuroepithelial precursors.
    • Further research into the molecular mechanisms of this differentiation could inform novel therapeutic strategies for brain tumors.

    Related Experiment Videos