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Related Experiment Videos

Effects of isometric handgrip and dynamic exercise on left-ventricular function

C A Peter, R H Jones

    Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    |December 1, 1980
    PubMed
    Summary

    Bicycle exercise is superior to handgrip stress for detecting coronary artery disease. Radionuclide angiocardiography revealed that bicycle exercise effectively identifies left-ventricular dysfunction, unlike handgrip stress.

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    Area of Science:

    • Cardiology
    • Nuclear Cardiology
    • Diagnostic Imaging

    Background:

    • Assessing cardiac function is crucial for diagnosing coronary artery disease (CAD).
    • Non-invasive methods like radionuclide angiocardiography (RNA) are used to evaluate cardiac performance under stress.
    • Comparing different stress modalities is essential for optimizing diagnostic accuracy.

    Purpose of the Study:

    • To compare the efficacy of isometric handgrip and bicycle exercise stress tests in conjunction with radionuclide angiocardiography for detecting coronary artery disease.
    • To evaluate the impact of each stress modality on left-ventricular function and cardiac output in normal subjects and CAD patients.

    Main Methods:

    • Radionuclide angiocardiography was performed on 10 healthy volunteers and 20 patients with documented CAD.

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  • Cardiac function was assessed during two stress conditions: isometric handgrip and bicycle exercise.
  • Key parameters evaluated included cardiac output, heart rate, left-ventricular ejection fraction, and regional wall motion abnormalities.

    • Main Results:

    • Isometric handgrip induced a minor increase in cardiac output with no significant change in left-ventricular function; wall motion abnormalities were detected in only 45% of CAD patients.
    • Bicycle exercise in normal subjects showed an increased left-ventricular ejection fraction with stable cardiac volumes.
    • Failure to increase left-ventricular ejection fraction by ≥0.05 during bicycle exercise accurately identified 19 of 20 CAD patients, with no false positives.

    Conclusions:

    • Bicycle exercise elicits a more pronounced cardiovascular response compared to isometric handgrip stress.
    • Bicycle exercise, when combined with radionuclide angiocardiography, is a more effective stress modality for detecting left-ventricular dysfunction indicative of coronary artery disease.