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Interlaboratory salicylate variability

K D Mutchie, G H Saunders, A S Hanissian

    The Journal of Rheumatology
    |September 1, 1980
    PubMed
    Summary
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    Salicylate testing for juvenile rheumatoid arthritis patients showed significant variations between laboratories and methods. Reliable drug concentration measurements are crucial for safe and effective patient treatment.

    Area of Science:

    • Clinical Chemistry
    • Pharmacology
    • Pediatric Rheumatology

    Background:

    • Accurate salicylate level monitoring is essential for managing juvenile rheumatoid arthritis (JRA).
    • Variability in laboratory testing can impact clinical decision-making.
    • Previous studies have indicated potential discrepancies in salicylate assays.

    Purpose of the Study:

    • To evaluate the reliability of salicylate concentration determinations across different laboratories and methods.
    • To highlight the importance of laboratory accuracy in pediatric drug monitoring.

    Main Methods:

    • Nineteen patients with JRA underwent salicylate concentration testing.
    • Samples were analyzed in two initial laboratories, followed by testing in four laboratories using known salicylate samples.

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  • Comparison of results obtained from spectrofluorometric and Trinder methods was performed.

    • Main Results:

    • Significant variations in salicylate concentration measurements were observed between the laboratories.
    • The spectrofluorometric and Trinder methods yielded notably different results.
    • Discrepancies were evident even when using standardized salicylate samples.

    Conclusions:

    • There is a critical need for physicians and clinical pharmacists to verify the accuracy of laboratory salicylate determinations.
    • Inconsistent results can lead to inappropriate adjustments in patient medication regimens.
    • Ensuring laboratory reliability is paramount for the safe and effective management of JRA patients receiving salicylate therapy.