Androgen metabolism in the epithelium of the bovine cornea

The metabolism of [14C]-testosterone and [14C]-androstenedione resp. was investigated in the epithelium of the cow cornea. [14C]-testosterone was converted mainly to androstenedione (48.3%), while conversion to dihydrotestosterone accounted only for 2%. On incubation of androstenedione mainly testosterone was formed (9.8%) and polar, probably hydroxylated, substances (7.6%).