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Related Experiment Videos

Serum prolactin after electroconvulsive therapy in man

I Klimes, M Vigas, J Jurcovicová

    Endokrinologie
    |November 1, 1978
    PubMed
    Summary

    Electroconvulsive therapy (ECT) significantly increases serum prolactin (PRL) in male psychiatric patients, even with high initial levels. Alpha-adrenergic blockade did not alter this stress-induced hormone release.

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    Area of Science:

    • Neuroendocrinology
    • Psychopharmacology

    Background:

    • Electroconvulsive therapy (ECT) is a psychiatric treatment.
    • Chlorpromazine can elevate serum prolactin (PRL) levels.
    • The neuroendocrine response to ECT requires further investigation.

    Purpose of the Study:

    • To investigate the effect of ECT on serum prolactin (PRL) levels in male psychiatric patients.
    • To determine the role of alpha-adrenergic receptors in ECT-induced PRL release.

    Main Methods:

    • Administered ECT without anticonvulsive premedication to male psychiatric patients.
    • Measured serum PRL levels at baseline, 30 minutes, and 60 minutes post-ECT.
    • Administered phentolamine infusion prior to ECT in a subset of patients.

    Main Results:

    • Serum PRL levels increased significantly after ECT, peaking at 30 minutes.
    • PRL levels declined towards baseline by 60 minutes post-ECT.
    • Phentolamine infusion did not affect the ECT-induced PRL response.

    Conclusions:

    • Stress-induced PRL release during ECT is not inhibited by high initial PRL levels.
    • Alpha-adrenergic receptors appear to play a minimal role in ECT-induced PRL secretion.

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