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Updated: Jul 31, 2026

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
Published on: July 30, 2014
The association of alpha-actinin with the plasma membrane
Abstract:
The role of alpha-actinin in the attachment of actin to plasma membranes has been investigated. Specific antibody staining of SDS gels has indicated that alpha-actinin is a major component in isolated plasma membranes prepared from three different cell types by two different procedures. Using specific extraction conditions, most of the alpha-actinin can be selectively extracted from the membranes with relatively little parallel release of actin. This selective dissociation of alpha-actinin from the plasma membrane leads us to conclude that alpha-actinin is present in these membrane preparations, because it is bound to actin, and that alpha-actinin does not form a direct link between actin and the membrane.
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