Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitrogen mustards derived from alpha-hydroxymethyleneketones

E Mariani, A Tasca, G Bignardi

    Il Farmaco; Edizione Scientifica
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

    Physical review letters·2026
    Same author

    Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

    Physical review letters·2026
    Same author

    Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

    Physical review letters·2026
    Same author

    First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

    Physical review letters·2026
    Same author

    Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

    Physical review letters·2026
    Same author

    First Observation of the B[over ¯]_{s}^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay and Evidence for the B[over ¯]^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay.

    Physical review letters·2026

    New nitrogen mustards, alpha-[Bis-(2-chloroethyl)]aminomethyleneketones, were synthesized and tested. Some compounds, including a novel bornanone derivative, demonstrated activity against P388 lymphocytic leukemia in mice.

    Area of Science:

    • Organic Chemistry
    • Medicinal Chemistry
    • Pharmacology

    Background:

    • Nitrogen mustards are a class of alkylating agents with known cytotoxic properties.
    • Developing novel nitrogen mustard derivatives is crucial for identifying new anticancer agents.

    Purpose of the Study:

    • To synthesize novel alpha-[Bis-(2-chloroethyl)]aminomethyleneketones.
    • To synthesize a novel bornanone derivative containing a bis-(2-chloroethyl)amino moiety.
    • To evaluate the in vivo anticancer activity of these synthesized compounds against P388 lymphocytic leukemia.

    Main Methods:

    • Synthesis of alpha-[Bis-(2-chloroethyl)]aminomethyleneketones from alpha-hydroxymethyleneketones and N-(2-chloroethyl)-2-chloroethanamine.
    • Synthesis of 3-[2-(2-chloroethylthio)ethyl]aminomethylene-2-bornanone from 2-(2-chloroethylthio)ethanamine and 3-hydroxymethylene-2-bornanone.

    Related Experiment Videos

  • In vivo evaluation of compound activity against P388 lymphocytic leukemia in mice.

    • Main Results:

    • Successful synthesis of alpha-[Bis-(2-chloroethyl)]aminomethyleneketones.
    • Successful synthesis of a novel bornanone derivative, 3-[2-(2-chloroethylthio)ethyl]aminomethylene-2-bornanone.
    • Both 3-[2-(2-chloroethylthio)ethyl]aminomethylene-2-bornanone and 3-[bis-(2-chloroethyl]aminoemthylene-2-norbornanone exhibited activity against P388 lymphocytic leukemia.

    Conclusions:

    • Novel nitrogen mustard derivatives were synthesized, expanding the chemical space for potential anticancer drugs.
    • The synthesized bornanone derivatives show promise as cytotoxic agents.
    • Further investigation into these compounds could lead to the development of new leukemia therapies.