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Updated: Aug 11, 2026

Localization of the Locus Coeruleus in the Mouse Brain
Published on: March 7, 2019
Evidence for a role of the locus coeruleus noradrenaline system in learning
Abstract:
The effect of the new noradrenaline (NA) neurotoxin, DSP4, on the acquisition of one-way and two-way active avoidance responses was studied in rats. This treatment caused a marked degeneration of the locus coeruleus NA system and markedly impaired both one- and two-way avoidance acquisition. Both effects were blocked by pretreatment with desipramine, a NA uptake blocking agent. The present findings support the hypothesis that the locus coeruleus NA system in its entire extent may play a role in aversive learning.
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