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Lysosomal acid phosphatase decrease in nutritional encephalopathy in chicks

Y Dror, P Budowski

    Nutrition and Metabolism
    |January 1, 1980
    PubMed
    Summary
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    Vitamin E deficiency in chicks induced encephalopathy, significantly reducing bound acid phosphatase activity in the cerebellum. This highlights vitamin E

    Area of Science:

    • Biochemistry
    • Neuroscience
    • Nutritional Science

    Background:

    • Vitamin E is crucial for neurological health.
    • Oxidized oils can impact nutrient availability and health.
    • Acid phosphatase is an enzyme involved in cellular processes.

    Purpose of the Study:

    • To investigate the effects of vitamin E deficiency and thermally oxidized safflower oil on chick encephalopathy.
    • To examine the activity of acid phosphatase in the cerebellum, cerebrum, and liver of affected chicks.

    Main Methods:

    • Inducing encephalopathy in 14-day-old chicks using a vitamin E-deficient diet with 15% thermally oxidized safflower oil.
    • Measuring bound and free acid phosphatase activity in the cerebellum, cerebrum, and liver of deficient and control chicks.

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    Main Results:

    • Chicks fed a vitamin E-deficient diet exhibited encephalopathy.
    • Markedly lower bound acid phosphatase activity was observed in the cerebellum of deficient chicks compared to controls.
    • Free acid phosphatase activity also showed a tendency to be lower in the cerebellum of deficient chicks.
    • No significant differences in enzyme activities were found in the cerebrum and liver.

    Conclusions:

    • Vitamin E deficiency, exacerbated by thermally oxidized safflower oil, leads to encephalopathy in chicks.
    • Cerebellar bound acid phosphatase activity is significantly reduced in vitamin E-deficient encephalopathic chicks.
    • The cerebellum appears to be a primary target for the enzymatic changes associated with this induced neurological condition.