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Pyrosequencing for Microbial Identification and Characterization
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Pyrimidine-specific chemical reactions useful for DNA sequencing

C M Rubin, C W Schmid

    Nucleic Acids Research
    |October 24, 1980
    PubMed
    Summary

    Potassium permanganate and hydroxylamine hydrochloride selectively modify DNA bases. These reactions are adapted for the Maxam-Gilbert chemical sequencing method, enabling precise DNA analysis.

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