[Enzymatic changes in chronic pesticide exposure]

Activity of some enzymes (GOT, GPT, OCT, AP, GGTP, HE) was studied in a group of 74 workers, exposed to professional chronic combined pesticide effects. Enzyme changes were followed up depending on exposure. There was a statistically significant increase in GOT, GPT and OCT activities and decrease in HE. Paralleling this, an insignificant depression of AP and GGTP in comparison with the control group was observed. The relationship between these enzyme changes and liver function are discussed. Implication of toxic factor in the development of these changes is suggested.