An invitro study on the effect of prostaglandin E2 and F2 alpha on E-rosette forming activity of normal lymphocytes

The effects of PGE2 and F2 alpha have been studied on E-rosette forming activity of normal human peripheral blood lymphocytes. Addition of both PGs into the incubation medium caused a significant and concentration - dependent inhibition of E-rosette formation. The minimum effective concentration of both PGs was found to be 10(-9) M and complete inhibition was obtained when the concentration was increased to 10(-7) M. Possible mechanisms of the action of PGs on E-rosette formation are discussed.