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A new vena cava filter: experimental animal evaluation

C Gianturco, J H Anderson, S Wallace

    Radiology
    |December 1, 1980
    PubMed
    Summary
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    A novel wire mesh vena cava filter proved effective in dogs, maintaining vessel patency and trapping clots. Intimal proliferation ensured stable filter placement for up to eight weeks.

    Area of Science:

    • Vascular surgery
    • Biomedical engineering
    • Medical device development

    Background:

    • Inferior vena cava filters are crucial for preventing pulmonary embolism.
    • Existing filters can have complications like thrombosis and migration.
    • A need exists for improved filter designs with enhanced safety and efficacy.

    Purpose of the Study:

    • To evaluate a new hypothrombogenic vena cava filter in a canine model.
    • To assess the filter's efficacy in trapping emboli and its effect on vena cava patency.
    • To determine the long-term stability and biocompatibility of the novel filter design.

    Main Methods:

    • A thin wire mesh vena cava filter (0.152mm thick) was implanted in 18 dogs via the femoral vein using a 6.5 French catheter.
    • Filters were left in situ for up to eight weeks.

    Related Experiment Videos

  • Vena cava patency and filter performance in trapping radiopaque clots were assessed.

    • Main Results:

    • The vena cava remained patent in all 18 dogs throughout the study period.
    • The filters successfully trapped all injected radiopaque clots larger than 1-2mm.
    • Intimal proliferation at the filter-vena cava interface provided stable filter positioning.

    Conclusions:

    • The new wire mesh vena cava filter demonstrated excellent patency and effective emboli trapping in a canine model.
    • The observed intimal proliferation suggests good biocompatibility and secure long-term fixation.
    • This novel filter design shows promise for clinical application in preventing pulmonary embolism.