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[Mechanism of fasting hyperuricemia]
Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
|November 1, 1980
Summary
Fasting increases serum uric acid in obese patients due to reduced uric acid clearance and increased cellular nucleic acid breakdown. Benzbromarone did not alter these fasting effects.
Area of Science:
- Metabolism and Endocrinology
- Nephrology
Context:
- Investigating the physiological impact of short-term fasting on uric acid levels in obese individuals.
- Examining the role of benzbromarone, a uricosuric agent, during fasting-induced hyperuricemia.
Purpose:
- To elucidate the mechanisms behind fasting-induced hyperuricemia.
- To assess the effect of benzbromarone on uric acid metabolism during fasting.
Summary:
- Obese patients undergoing a 7-day fast showed elevated serum uric acid levels (from 49.37 to 90.52 mg/L) and decreased uric acid clearance (to 4.67 ml/min).
- Uric acid turnover doubled, and the miscible pool increased 3.5-fold in control subjects during fasting.
- Benzbromarone administration did not significantly alter these observed changes in uric acid metabolism during fasting.
Impact:
- Provides insight into the dual causes of fasting hyperuricemia: reduced renal clearance and increased endogenous production.
- Highlights that benzbromarone does not mitigate the metabolic disturbances of uric acid during short-term fasting in obese individuals.
- Contributes to understanding metabolic shifts during caloric restriction and their implications for conditions like gout.