[Chronic meningo-cutaneo-articular syndrome in children]

The authors describe the case records of 3 unrelated children with a syndrome which started during the neonatal period and had a chronic course. This syndrome consisted of inflammatory joint disease involving all the large joints symmetrically, causing radiological lesions with a "bread crumb' appearance of the epiphyses and of the patella, ossified too early, with skin lesions, and neurological signs with persistence of chronic meningitis with neutrophil polymorphs and eosinophils. Infiltration by polymorphs of various organs e.g. skin, lymph nodes, synovial fluid and peripheral blood characterise this syndrome.