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Clostridium paraputrificum sepsis in sickle cell anemia
Southern Medical Journal
|December 1, 1980
Insights
Clostridial sepsis can occur in children with sickle cell disease, presenting as an abdominal crisis. Clostridium paraputrificum is a newly identified cause of sepsis in these patients.
Area of Science:
- Pediatric Infectious Diseases
- Hematology
Background:
- Sickle cell disease (SCD) is a genetic blood disorder associated with increased risk of infections.
- Abdominal crises are a common complication in children with SCD.
Observation:
- A pediatric patient with SCD experienced an abdominal crisis.
- The patient developed sepsis during this crisis.
Findings:
- Clostridium paraputrificum was identified as the causative agent of sepsis.
- This represents a novel association between C. paraputrificum and SCD.
Implications:
- Clostridium paraputrificum should be considered in the differential diagnosis of sepsis in SCD patients.
- This finding expands the spectrum of known pathogens causing sepsis in individuals with sickle cell anemia.
Abstract:
We have described clostridial sepsis in a child who presented with an abdominal crisis of sickle cell disease. Clostridium paraputrificum should be included in the list of organisms known to cause sepsis in patients with sickle cell anemia.