Serum inhibitory factors and E rosettes in chronic renal failure

The inhibiting effect of uraemic serum on both normal and uraemic lymphocytes capacity to form E rosettes was studied in 10 uraemic patients and 14 healthy controls. Uraemic serum was found to significantly inhibit E rosette forming cells of normal and uraemic lymphocytes. On the other hand, E rosettes of uraemic patients ranged in normal values after incubation in normal serum. These findings suggest that rosette inhibiting factors are present in uraemia and that uraemic T lymphocyte sheep erythrocyte rosette function is intact.