[Histological and enzyme histochemical studies of intestinal interposition after total gastrectomy]

The formation of a stomach substitute with various intestinal interpolations (jejunum, ileocecum, colon) and the esophagojejunostomy by a Roux-anastomosis are carried through after total gastrectomy in animal experiments. The structural rebuilding proceedings in the intestinal interpolations were histologically and enzyme-histochemically examined after an experimental time of 3 months. A dilatation of the intestinal wall in connection with muscular wall hypertrophy appears in all operating method. In that way the reservoir function is guaranteed in the various stomach substitutes. The mucosa of the jejunal interpolation shows a hyperregeneratoric atrophy. A small enlargement of the surface originates in the colon interpolation from a villiferous conversion of the proximal parts of the crypts. The advance of the activity of the brush border enzymes in the ileocecum and the colon interpolation refers to an attempt of the mucosa on a change of the conditions of resorption. The essential pathogenetic factor of all rebuilding events appears in the intralumic environmental alteration in the intestinal interpolations.