[Angio-immunoblastic lymphadenopathy and local immuno-reactions of the lymph nodes (author's transl)]

Report on histological findings in lymph nodes, spleen, bone marrow, liver, lungs and kidneys in angio-immunoblastic lymphadenopathy and comparison with localized immuno-reactions of lymph nodes. Beside principal similarities in cellular and vascular proliferation differences may be noticed in the degree of preservation of the lymphonodular architecture, in the degree of proliferation of "immune cells" and postcapillary venules, and in the height of their endothelium. While for local immuno-reactions of the lymph nodes a regulated course may be supposed, the reaction in angio-immunoblastic lymphadenopathy is interpreted as an expression of dysregulation--presumably concerning to the function of T-cells--which occasionally may lead to a transformation into malignant lymphoma. Possible initial stages of this transformation are demonstrated by means of an own observation.