[The pathology of ganglion]

Ganglia are cysts which frequently occur in the proximity of joints. Histopathologic examinations disclose that these formations do not originate from articular tissue, but independently of this develop from degenerating nonspecific connective tissue. By progressive myxoid decomposition of collagen fibers larger amounts of mucinous fluid accumulate, and spread the adjacent collagen fibers apart, thus forming cavities filled with thickening fluid. With further liquefaction of some interstitial septa some cysts coalesce and widen, until eventually other septa and the surrounding capsule become dense by increase of fibrocytes and thickening of the collagen bundles.