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[Liver function in acute urinary tract infection]
Acta Paediatrica Academiae Scientiarum Hungaricae
|January 1, 1980
Summary
Early infantile hyperbilirubinemia in infants warrants screening for urinary tract infections, which can be asymptomatic. Bromosulphalein (BSP) retention in pyelonephritis may indicate disease severity due to bacterial toxins.
Area of Science:
- Pediatrics
- Nephrology
- Hepatology
Context:
- Infantile hyperbilirubinemia (jaundice) can be linked to urinary tract infections (UTIs).
- Pyelonephritis, a kidney infection, may present with or without jaundice in children.
- Gram-negative bacteria in UTIs can have toxic effects on liver function.
Purpose:
- To investigate the association between pyelonephritis and icterus in young infants.
- To evaluate liver function in children with pyelonephritis without hyperbilirubinemia.
- To determine if Bromosulphalein (BSP) retention can indicate disease severity in pyelonephritis.
Summary:
- A study observed pyelonephritis associated with icterus in 26 young infants, suggesting screening for asymptomatic bacteriuria in cases of early infantile hyperbilirubinemia.
- Liver function tests in 21 children with pyelonephritis (without jaundice) revealed pathological BSP retention in 6 infants.
- This BSP retention is hypothesized to result from toxic effects of Gram-negative bacteria, potentially indicating disease severity.
Impact:
- Highlights the importance of searching for UTIs in infants with hyperbilirubinemia.
- Suggests BSP retention as a potential biomarker for pyelonephritis severity.
- Informs clinical practice regarding the diagnosis and management of UTIs and liver dysfunction in pediatric patients.