Studies on metabolic kinetics of lead and alkaline earth elements (Ca, Ba)

In this work, results of investigations of the rate of lead incorporation into compact bone tissue are presented and compared with analogous investigation carried out on calcium and barium. The investigations were conducted using the isotopes 201Pb, 133Ba, 45Ca, with a small quantity of appropriate lead, barium or calcium carrier. The isotopes were administered to groups of rabbits of Chinchila strain (8 rabbits for 210Pb, 33 for 133Ba and 35 for 45Ca) in a single intravenous injection. The content of 210Pb, 133Ba, or 45Ca was determined in femoral and tibial bone shafts and in the plasma by radiochemical nethods. The results indicated that the addition rate of 210Pb into bone tissue from the plasma is about twice as high as the rate of 45Ca addition and it approximates the rate for 133Ba.