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Decrease in peritoneal mast cell count in rats with adjuvant arthritis. I. Time course and interstrain difference

S Seo, J Yokoyama, K Saeki

    Agents and Actions
    |September 1, 1980
    PubMed
    Summary
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    Adjuvant injection in rats caused mast cell redistribution from peritoneal fluid to surrounding tissues, particularly in Sprague-Dawley (SD) rats, correlating with polyarthritis development. This suggests a role for mast cells in delayed hypersensitivity responses.

    Area of Science:

    • Immunology
    • Pathology

    Background:

    • Adjuvant injections are used to induce inflammatory responses in animal models.
    • Mast cells and histamine play roles in inflammatory and hypersensitivity reactions.

    Purpose of the Study:

    • To investigate the effect of adjuvant injection on mast cell count and histamine content in different tissues.
    • To compare the responses between Sprague-Dawley (SD) and Wistar rat strains.

    Main Methods:

    • Adjuvant was injected into the left hind paw of SD and Wistar rats.
    • Mast cell counts and histamine content were measured in peritoneal fluid, mesentery, caecum, and skin.

    Main Results:

    • SD rats showed decreased mast cells and histamine in peritoneal fluid, with increased levels in the mesentery, 1-2 weeks post-injection.

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  • These changes in SD rats correlated with the development of polyarthritis.
  • Wistar rats exhibited a tendency towards increased mesenteric histamine, but less pronounced changes than SD rats.

    • Conclusions:

    • Adjuvant administration induces a redistribution of mast cells from peritoneal fluid to mesenteric tissue.
    • This redistribution is likely mediated by delayed hypersensitivity and is more pronounced in SD rats.
    • The findings highlight the dynamic role of mast cells in adjuvant-induced inflammation and arthritis.