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Related Experiment Videos

Retinopathy after tilorone hydrochloride

J N Weiss, A L Ochs, S Abedi

    American Journal of Ophthalmology
    |December 1, 1980
    PubMed
    Summary

    Tilorone HCl, an experimental antitumor drug, caused ocular toxicity in two patients, including corneal infiltrates and retinopathy. Early detection through extensive testing is crucial for patients receiving this medication.

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    Area of Science:

    • Ophthalmology
    • Pharmacology
    • Oncology

    Background:

    • Tilorone hydrochloride is an experimental antitumor agent.
    • Antioxidants can influence retinal pigment epithelium function.

    Observation:

    • Two female patients developed ocular side effects after oral administration of tilorone HCl.
    • Ocular findings included corneal subepithelial infiltrates, toxic retinopathy with pigment mottling, and arteriolar narrowing.

    Findings:

    • Patient 1 experienced peripheral visual field constriction and abnormal electroretinogram/electro-oculogram despite maintained visual acuity.
    • Patient 2 showed severe arteriolar narrowing and attenuated ERG/EOG, with normal visual fields.
    • Tilorone HCl may act as an antioxidant, potentially affecting retinal pigment epithelium free radical scavenging.

    Implications:

    • Tilorone HCl can induce significant ocular toxicity, including retinopathy.
    • Close ophthalmological monitoring is essential for patients undergoing tilorone HCl treatment.
    • Understanding the drug's antioxidant properties may elucidate its mechanism of ocular toxicity.

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