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Updated: Aug 18, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
The symptoms of major depressive illness
Abstract:
The authors suggest that the common characteristics of various descriptions of major depressive illness--endogenous, endogenomorphic, psychotic, and melancholic--are an autonomous course, a need for biological treatment, and a presumed alteration in neurochemistry. The literature is reviewed to determine those symptoms which best characterize this syndrome. These symptoms may prove useful in developing valid diagnostic criteria for major depressive illness.
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