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Related Experiment Videos

Standardized allergen provocation test. Variation in bronchial response

O Loẅhagen, N B Lindholm

    Allergy
    |June 1, 1980
    PubMed
    Summary

    Standardized bronchial allergen provocation shows moderate, predictable airway responses in asthmatic patients. This method is reliable for studying asthma pathophysiology and evaluating new anti-asthma medications.

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    Area of Science:

    • Allergy and Immunology
    • Pulmonary Medicine
    • Clinical Research

    Background:

    • Asthma management requires reliable methods to assess airway hyperresponsiveness.
    • Understanding bronchial allergen provocation test (BPT) variability is crucial for its clinical application.

    Purpose of the Study:

    • To investigate the variability of bronchial responses to standardized allergen provocation in asymptomatic adult asthmatics.
    • To assess the suitability of BPT for pathophysiological studies and drug evaluations.

    Main Methods:

    • Repeated standardized bronchial allergen provocation (3-9 times) in 20 adult asthmatics over 0.5-22 months.
    • Monitoring of FEV1, FVC, PEFR, and MEF50% for immediate reactions post-provocation.
    • Analysis of variability using the coefficient of variation (CV) for FEV1 decrease.

    Main Results:

    • A highly significant correlation was found between FEV1 and other respiratory variables.
    • The coefficient of variation for the maximum decrease in FEV1 was 23%.
    • All provocations resulted in bronchial reactions within acceptable clinical limits, with no signs of sensitization changes.

    Conclusions:

    • Careful standardization of BPT procedures yields moderate and predictable bronchial response variations.
    • Standardized BPT is a suitable method for asthma pathophysiological studies.
    • BPT can be effectively used for the clinical evaluation of anti-asthmatic drugs.

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