Related Experiment Video

Updated: Jan 30, 2026

A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation
10:55

A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation

Published on: January 13, 2023

2.3K

Calcium and cardiac arrest

J Bull, D M Band

    Anaesthesia
    |November 1, 1980
    PubMed

    Insights

    This study compared calcium chloride and calcium gluconate for cardiac arrest treatment. Ionized calcium levels in blood showed no significant difference between the two preparations, challenging claims of superior availability.

    Area of Science:

    • Cardiology
    • Biochemistry
    • Emergency Medicine

    Background:

    • Calcium preparations are vital in cardiac arrest management.
    • Claims exist that certain calcium formulations offer superior cardiac availability.
    • Understanding calcium bioavailability is crucial for effective resuscitation.

    Purpose of the Study:

    • To compare the bioavailability of ionized calcium from calcium chloride and calcium gluconate.
    • To evaluate if formulation differences impact ionized calcium levels in human blood during simulated cardiac arrest interventions.

    Main Methods:

    • Assay of ionized calcium levels in human blood samples.
    • Addition of standardized calcium increments using both calcium chloride and calcium gluconate.
    • Utilized a precise calcium electrode for accurate measurements.

    Main Results:

    • No statistically significant difference was observed in ionized calcium levels between calcium chloride and calcium gluconate.
    • Both preparations increased ionized calcium concentrations similarly.
    • The study found comparable calcium availability to the blood.

    Conclusions:

    • The bioavailability of ionized calcium from calcium chloride and calcium gluconate is similar.
    • Current evidence does not support claims of one preparation being significantly advantageous over the other in terms of immediate calcium availability.
    • Further research may be needed to explore other potential differences in clinical efficacy.

    More Related Videos

    In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter05:04

    In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

    Published on: February 22, 2022

    3.8K
    Normothermic Cardiac Arrest and Cardiopulmonary Resuscitation: A Mouse Model of Ischemia-Reperfusion Injury10:25

    Normothermic Cardiac Arrest and Cardiopulmonary Resuscitation: A Mouse Model of Ischemia-Reperfusion Injury

    Published on: August 30, 2011

    18.7K

    Related Concept Videos

    The Cardiac Cycle01:13

    The Cardiac Cycle

    The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).
    The Process
    Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and...
    98.1K
    Cardiac Cycle01:29

    Cardiac Cycle

    The cardiac cycle refers to the sequence of events that occur in the heart from the beginning of one heartbeat to the next. It's characterized by alternating periods of contraction (systole) and relaxation (diastole) of the heart muscles.
    During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
    12.8K
    Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

    Cardiac Output II: Effect of Stroke Volume on Cardiac Output

    Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
    Preload
    Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
    3.3K
    Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

    Cardiac Output I:Effect of Heart Rate on Cardiac Output

    Cardiac Output
    Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
    Effect of Heart Rate on Cardiac Output
    Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
    2.6K
    Skeleton and Calcium Homeostasis01:21

    Skeleton and Calcium Homeostasis

    Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
    5.9K
    Exercise and Cardiac Output01:17

    Exercise and Cardiac Output

    Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
    Sustained exercise increases the muscles' oxygen demand, which can be...
    1.9K