Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pallidosubthalamic projection in the cat. Electron microscopic study

K V Romansky, K G Usunoff, D P Ivanov

    Anatomy and Embryology
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    In Vitro Tissue Microarrays for Quick and Efficient Spheroid Characterization.

    SLAS discovery : advancing life sciences R & D·2017
    Same author

    Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.

    Data in brief·2016
    Same author

    Experimental demonstration of intrinsic synapses in cat's caudate nucleus.

    Neuroscience letters·2009
    Same authorSame journal

    Nitric oxide synthase-containing neurons in the amygdaloid nuclear complex of the rat.

    Anatomy and embryology·2006
    Same author

    Brain stem afferent connections of the amygdala in the rat with special references to a projection from the parabigeminal nucleus: a fluorescent retrograde tracing study.

    Anatomy and embryology·2006
    Same author

    Serosal membranes (pleura, pericardium, peritoneum). Normal structure, development and experimental pathology.

    Advances in anatomy, embryology, and cell biology·2006

    Electron microscopy revealed degenerative changes in cat subthalamic nucleus (Sth) terminals after external pallidum lesions. Degenerating F1 terminals primarily contacted large Sth neurons, supporting existing research on basal ganglia circuitry.

    Area of Science:

    • Neuroscience
    • Electron Microscopy
    • Basal Ganglia Research

    Background:

    • The subthalamic nucleus (Sth) plays a crucial role in basal ganglia motor control.
    • Understanding the connectivity and neuronal degeneration patterns within the Sth is vital for neurodegenerative disease research.

    Purpose of the Study:

    • To investigate the ultrastructural changes in the cat's subthalamic nucleus following external pallidum lesions.
    • To identify the specific neuronal terminals undergoing degeneration and their synaptic targets within the Sth.

    Main Methods:

    • Lesions were induced in the external pallidum of cats.
    • Subthalamic nucleus tissue was examined using electron microscopy 4-5 days post-lesion.
    • Degenerating terminals were characterized based on their ultrastructural morphology and synaptic relationships.

    Related Experiment Videos

    Main Results:

    • A significant number of degenerating terminals were observed in the ipsilateral Sth, with no degeneration in the contralateral Sth.
    • The degenerating terminals, identified as F1 terminals, predominantly contacted perikarya and proximal dendrites of large Sth neurons.
    • Degeneration patterns included light and dark types, with some showing filamentous hyperplasia.

    Conclusions:

    • The findings confirm that F1 terminals projecting to the Sth originate from the external pallidum.
    • The observed degeneration patterns and synaptic targets align with previous morphological and physiological studies.
    • This research corroborates existing data on the basal ganglia circuitry and the impact of pallidal lesions.