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Updated: Aug 14, 2026

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
Published on: February 6, 2018
[Comparison between testicular biopsies and biopsy smears in azoospermia]
Abstract:
The diagnostic results of testicular biopsies were compared to the results of biopsy smear cytology in 25 patients with azoospermia. Sufficient correct diagnosis was made cytologically in 23 cases. In two cases of incomplete spermatogenetic arrest, cytology was inconclusive and no cytological diagnosis could be made. The diagnostic results are based on a rough population analysis. Evaluation of the tubuli, basal membrane and interstitial tissue can not be made in cytological material. Good diagnostic results can only be obtained if a satisfactory cytological specimen is examined i.e. material containing spermatogenetic and/or Sertoli cells.

