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Related Experiment Videos

Acral lentiginous melanoma

N Shiffman, K A Arndt, J M Noe

    Annals of Plastic Surgery
    |September 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Acral lentiginous melanoma, a rare skin cancer on hands and feet, grows laterally then vertically. Early diagnosis is crucial as deeper invasion correlates with poorer prognosis.

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    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Acral lentiginous melanoma (ALM) is a rare subtype of cutaneous melanoma.
    • It predominantly affects the palms, soles, and subungual regions.
    • ALM is known for its distinct growth patterns and potential for delayed diagnosis.

    Observation:

    • This melanoma type exhibits a characteristic two-phase growth: an initial lateral spreading phase followed by a vertical invasive phase.
    • Diagnosis can be challenging due to its location and appearance, often requiring multiple biopsies or complete excision of suspicious lesions.
    • The presented case highlights the diagnostic difficulties associated with ALM.

    Findings:

    • Prognosis in acral lentiginous melanoma, similar to other melanoma subtypes, is significantly influenced by the depth of tumor invasion at the time of diagnosis.

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  • Deeper invasion is associated with a poorer patient outcome.

    • Implications:

    • Emphasizes the critical need for thorough evaluation and potentially invasive diagnostic procedures for pigmented lesions on the extremities.
    • Highlights the importance of early detection and accurate staging for improving therapeutic strategies and patient survival in ALM.
    • Suggests that increased awareness and diagnostic vigilance are necessary among clinicians managing patients with suspected ALM.