Further observations on vesicourethral dopamine receptors--a urodynamic study with haloperidol

The effect of intravenous administration of 5 mg of haloperidol, a dopamine receptor antagonist upon cystometry, the urethral pressure profile, and the external urethral sphincter electromyography (EMG) was investigated in eight patients with neurogenic vesical dysfunction. There was no change in the detrusor reflex or in the sphincter EMG activities, but the peak urethral pressure decreased. The possible reasons for the difference in the above result as compared to our previous study using metoclopramide, another dopamine receptor antagonist, are discussed.